This innovative integrated systems biology application seeks to delineate the complex host/pathogen interactions occurring at the alveolar level that lead to unsuccessful response to therapy in serious pneumonia. The Administrative Core will be responsible for managing, coordinating, and supervising the entire range of SCRIPT Systems Biology Center activities. As such, the Administrative Core will intersect with all internal SCRIPT investigators as well as the NIAID sponsoring agency, other Systems Biology Centers, and the broader infectious diseases and pulmonary/critical care scientific communities. The SCRIPT Systems Biology Center is intentionally multidisciplinary, increasing the complexity of interactions and mandating a centralized approach to facilitate accomplishing the goals of this Systems Biology Center.